Early Detection of Periodontal Disease with the Periosafe Test (aMMP-8 Test)

[ Identify Tissue Degeneration in the Gums Early – with the Periosafe Rapid Test ]

Implant Safe Center

Periodontal degeneration typically progresses silently and remains undetected for a long time. KU64 is a certified Implant Safe Center. To detect early signs of gum tissue breakdown, KU64 specialists use the Periosafe test – helping to prevent disease and improve dental hygiene.

For over 30 years, KU64 has supported patients in oral health prevention and prophylaxis. In line with our values, we focus on preventive care through modern, pain-free professional cleanings and regular check-ups with our dental specialists.

Current studies show how vital this is: Experts estimate that around 28 million people in Germany suffer from treatable periodontitis. One in two people over the age of 40 is affected, yet only about one million are actually undergoing treatment.

The Periosafe rapid test detects hidden periodontal inflammation before it leads to tissue breakdown in the periodontium. This allows our dental experts to intervene early, initiate treatment, and monitor its success through follow-up tests.

Our team – especially our dentists – is happy to advise you on Periosafe and how to eliminate the problem of periodontitis from your life.

Schedule your test today by calling 030-8647320 or using our online appointment booking system!

aMMP-8 Test – Risk Factors Diagram

Implant wearers in particular should monitor their inflammation markers regularly. A recent periodontal study shows that a quarter of all implants show inflammation (peri-implantitis) after just nine years. Nearly 70% of implant patients unknowingly suffer from inflammation (periodontitis, gingivitis) and early bone loss around their implants.

This bone loss is triggered by a proteolytic enzyme called matrix metalloproteinase. Since this enzyme breaks down collagen, its presence is a reliable indicator that degeneration has begun – often long before symptoms appear.

As a certified Implant Safe Center, KU64 has the expertise to fully support you in keeping your implants healthy. With advanced oral diagnostics and personalized prophylaxis, the Implant Safe concept promotes lifelong implant health and helps avoid complications and additional costs. New rapid tests from Dentognostics are highly effective tools in maintaining your dental restorations.

What Does the Periosafe/aMMP-8 Test Do?

Periosafe by Dentognostics is the world’s first rapid test for the early detection of hidden gum tissue breakdown. It is especially effective for at-risk groups, as it can reveal undiagnosed periodontal inflammation involving granulocytes. Without the test, such inflammation might only become visible through probing or X-rays months or even years later. The test provides a fast overview of your oral hygiene status, allowing our dentists to initiate early treatment—ideally before symptoms arise.

We now offer enzyme diagnostics chairside in just 20 minutes, allowing us to accurately assess treatment needs using the Periodontal Screening Index (PSI). Follow-up tests confirm that therapy has effectively slowed tissue degradation.

The German Dental Association (DZV) has reviewed the scientific basis of this method and explicitly recommends reimbursement by health insurers.

To ensure the best results from your implant care program, we also recommend monitoring bone metabolism. This may be negatively impacted by undiagnosed diabetes or vitamin D deficiency—both of which we can now test.

The Mouth-Body Connection

Numerous clinical studies and interdisciplinary research confirm the strong link between periodontal disease (periodontitis) and the following conditions:

  • Diabetes

  • Endocarditis and cardiovascular disease

  • Rheumatoid arthritis

  • Osteoporosis

  • Inflammation around prosthetics (e.g., hip implants)

  • Respiratory conditions and chronic lung disease

  • Infertility and premature birth

This underscores the importance of monitoring your oral hygiene using tools like the Periosafe test. It plays a key role in preventing chronic disease and supporting a healthy immune system. That’s why regular check-ups with our oral health experts are so important.

Of course, proper oral hygiene starts with brushing and possibly mouthwash as part of your daily routine. This removes harmful bacteria that can damage the gums and lead to degradation. Exercise and a vitamin-rich diet also support oral health—but this is just the foundation. For comprehensive protection, regular testing is essential.

Preventive Dentistry – Early Detection Saves Teeth and Costs

We recommend regular testing for all patients over 35, as early detection of periodontal disease significantly reduces the risk of tooth loss. Preventive oral care is essential—and more affordable than tooth replacement. While many insurance plans cover periodontal treatment, they often don’t cover implants.

If your test result is positive, you can join our Perio Prevention Program. An interdisciplinary team will work to reduce your personal risk factors and restore your gum health—or even better, keep you healthy from the start.

Especially Important for Patients with Chronic Conditions

Patients with chronic conditions such as:

  • Diabetes

  • Rheumatism

  • Cardiovascular disease

…are more prone to periodontitis, often with more severe progression. With the Periosafe oral health test, which only takes five minutes, our experts can use aMMP-8 technology to detect early tissue or bone loss—information that is truly invaluable.

A positive result allows you and your KU64 dentist to discuss preventive steps in the early stages—preventing further damage, identifying gum pockets, and initiating treatment early.

The test can also be performed at home using a prescription from us. But of course, we are happy to perform it right here in the practice and discuss the results with you directly.

By participating in our preventive program, you also reduce your risk of heart attack and stroke and improve the treatability of rheumatoid arthritis and diabetes.

Infertility and Premature Birth

Our prevention program is particularly valuable for couples trying to conceive. In many cases, better oral health improves overall health and increases the chance of a long-awaited pregnancy. Oral health is a key factor in general wellbeing.

KU64 – Germany’s First Implant Safe Center

In 2022, KU64 became the first dental practice in Germany to be certified as an Implant Safe Center by the German Oral Health Foundation (DMS). We are now Berlin’s first PerioPrevention Center and among only a few in Germany to hold this certification in immunological diagnostic technology.

Why Were We Certified?

A simple saliva test with biomarkers can now detect impending inflammation around implants up to 24 months before visible damage occurs—with 94% predictive accuracy. Clinical studies show: targeted treatment and individualized prevention can prevent or slow severe complications.

This has been scientifically validated: researchers from the Universities of Marburg, Rome, and Helsinki have confirmed the effectiveness of the Implant Safe concept in clinical studies. Long-term research from the Netherlands supports this as well—showing implant inflammation can be halted or at least significantly slowed.

Get in Touch

Call us or book online to schedule your appointment and learn more about the Implant Safe concept. The sooner you act, the better your chances of protecting your oral and overall health.

Tel: 030-8647320
WhatsApp
Online appointment booking

F.A.Q. – Periosafe Test

It’s a rapid test designed to improve oral health. We offer this biomarker test affordably with every prophylaxis appointment. It can even help detect early signs of diabetes. Best of all—it’s completely painless. A simple saliva sample is all it takes. Naturally, the test is performed directly in our practice.

This patented, high-tech saliva diagnostic tool supports tooth preservation, implant protection, and overall health. It enables extremely early detection and treatment of periodontal disease—before serious damage can occur.

aMMP-8 stands for “activated matrix metalloproteinase 8.” It’s a natural enzyme in the body responsible for collagen breakdown. Detecting it in the mouth is a strong indicator that periodontitis may be developing.

A biomarker, as used in the Periosafe test, refers to measurable indicators of health. Many common medical tests rely on biomarkers—like body temperature when checking for fever. For complex conditions, rapid or lab tests are needed to detect proteins or chemical messengers in bodily fluids. In the case of the aMMP-8 test, the enzyme indicates a potentially harmful inflammatory response in the mouth.

It’s simple and painless. Our trained staff collects a saliva sample, and the result is ready in just five minutes.

We recommend it for all patients over 35. Depending on your condition or medical history, you may need more frequent testing.
It’s especially important for implant patients. If left untreated, degeneration of the periodontal tissue can lead to implant loss. The earlier it’s detected, the better it can be managed.
It’s also critical for those with chronic illnesses, as they’re more prone to advanced forms of the disease. Early diagnosis offers the best treatment options.

That depends on your dental and oral health condition. Your dentist will advise you on the ideal testing interval.

The test costs €64 for public insurance and self-pay patients. Private patients are reimbursed. Although recommended by professional associations, the test is not yet covered by statutory insurance providers.

Yes, you can get a prescription for self-testing at home, much like non-prescription medications. However, we also offer it in-house for your convenience.

Implants can’t get cavities or need root canals—but they can be lost due to peri-implantitis, a form of inflammation around the implant.
The innovation lies in improved diagnostics: using modern technology, we can detect early signs of bone loss long before damage occurs. As a certified Implant Safe Center, we combine systematic early detection with customized prevention to keep your implants healthy for life.

Dentognostics is the German company behind the Periosafe test, based in Solingen. They specialize in early detection of inflammatory processes in the periodontium through rapid and lab-based diagnostic solutions. Their products are marketed under the “Periosafe” brand.

The Deutsche Mundgesundheitsstiftung (DMS) is a public-interest foundation promoting awareness of inflammatory diseases of the oral cavity. It awards the “Implant Safe Center” certification to dental practices that meet high scientific standards in preventive care for implant patients.